Endocrine Abstracts

Adrenal cortical cells are continuously renewed in order to sustain production of relevant zonal steroids. Cell proliferation occurs at the periphery of the cortex where cells subsequently displace centripetally, switching phenotypically as they migrate though the gland and finally undergoing apoptosis at the medullary boundary. However, it is not known which mechanisms cause the cells to differentiate as they cross the zonal boundaries. A candidate group of genes involved in ...